]> Creatis software - clitk.git/blobdiff - segmentation/clitkExtractMediastinumFilter.txx
Moved from repository clitk to clitk.private/tests_dav
[clitk.git] / segmentation / clitkExtractMediastinumFilter.txx
index d3ba557b97d863cb7a486aab5c59c742a4f371b0..675718082192ea3663ada290675da3648b91a5e2 100644 (file)
 template <class ImageType>
 clitk::ExtractMediastinumFilter<ImageType>::
 ExtractMediastinumFilter():
-  clitk::FilterBase(),
-  clitk::FilterWithAnatomicalFeatureDatabaseManagement(),
-  itk::ImageToImageFilter<ImageType, MaskImageType>()
+  clitk::StructuresExtractionFilter<ImageType>()
 {
   this->SetNumberOfRequiredInputs(1);
-
   SetBackgroundValuePatient(0);
   SetBackgroundValueLung(0);
   SetBackgroundValueBones(0);
   SetForegroundValueLeftLung(1);
   SetForegroundValueRightLung(2);
-  SetBackgroundValue(0);
-  SetForegroundValue(1);
-
-  SetIntermediateSpacing(6);
-  SetFuzzyThreshold1(0.5);
-  SetFuzzyThreshold2(0.6);
-  SetFuzzyThreshold3(0.05);
-  
-  SetOutputMediastinumFilename("mediastinum.mhd");
-  
+  SetDistanceMaxToAnteriorPartOfTheVertebralBody(10);  
+  SetOutputMediastinumFilename("mediastinum.mha");  
   UseBonesOff();
 }
 //--------------------------------------------------------------------
@@ -121,6 +110,32 @@ SetInputTracheaLabelImage(const MaskImageType * image, MaskImagePixelType bg)
 }
 //--------------------------------------------------------------------
 
+//--------------------------------------------------------------------
+template <class ImageType>
+void 
+clitk::ExtractMediastinumFilter<ImageType>::
+SetFuzzyThreshold(std::string tag, double value)
+{
+  m_FuzzyThreshold[tag] = value;
+}
+//--------------------------------------------------------------------
+
+
+//--------------------------------------------------------------------
+template <class ImageType>
+double 
+clitk::ExtractMediastinumFilter<ImageType>::
+GetFuzzyThreshold(std::string tag)
+{
+  if (m_FuzzyThreshold.find(tag) == m_FuzzyThreshold.end()) {
+    clitkExceptionMacro("Could not find options "+tag+" in the list of FuzzyThresholds.");
+    return 0.0;
+  }
+  
+  return m_FuzzyThreshold[tag]; 
+}
+//--------------------------------------------------------------------
+
 
 //--------------------------------------------------------------------
 template <class ImageType>
@@ -133,7 +148,6 @@ GenerateInputRequestedRegion()
   // Superclass::GenerateInputRequestedRegion();  
   // DD("End GenerateInputRequestedRegion");
 }
-
 //--------------------------------------------------------------------
 
 
@@ -148,6 +162,7 @@ SetInput(const ImageType * image)
 //--------------------------------------------------------------------
 
 
+
 //--------------------------------------------------------------------
 template <class ImageType>
 void 
@@ -158,22 +173,21 @@ GenerateOutputInformation() {
 
   //--------------------------------------------------------------------
   // Get input pointers
-  clitk::PrintMemory(GetVerboseMemoryFlag(), "Initial memory"); // OK
-  LoadAFDB();
+  this->LoadAFDB();
   ImageConstPointer input = dynamic_cast<const ImageType*>(itk::ProcessObject::GetInput(0));
-  MaskImagePointer patient = GetAFDB()->template GetImage <MaskImageType>("Patient");  
-  MaskImagePointer lung = GetAFDB()->template GetImage <MaskImageType>("Lungs");
-  MaskImagePointer bones;
+  MaskImagePointer patient, lung, bones, trachea;
+  patient = this->GetAFDB()->template GetImage <MaskImageType>("Patient");
+  lung = this->GetAFDB()->template GetImage <MaskImageType>("Lungs");
   if (GetUseBones()) {
-    bones = GetAFDB()->template GetImage <MaskImageType>("Bones");  
+    bones = this->GetAFDB()->template GetImage <MaskImageType>("Bones");  
   }
-  MaskImagePointer trachea = GetAFDB()->template GetImage <MaskImageType>("Trachea");  
-    
-  clitk::PrintMemory(GetVerboseMemoryFlag(), "After read patient, lung"); 
-  
+  trachea = this->GetAFDB()->template GetImage <MaskImageType>("Trachea");  
+
+  //this->VerboseImageSizeFlagOn();
+
   //--------------------------------------------------------------------
-  // Step 1: Crop support (patient) to lung extend in RL
-  StartNewStep("Crop support like lungs along LR");
+  // Step : Crop support (patient) to lung extend in RL
+  this->StartNewStep("[Mediastinum] Crop support like lungs along LR");
   typedef clitk::CropLikeImageFilter<MaskImageType> CropFilterType;
   typename CropFilterType::Pointer cropFilter = CropFilterType::New();
   cropFilter->SetInput(patient);
@@ -181,11 +195,11 @@ GenerateOutputInformation() {
   cropFilter->Update();
   output = cropFilter->GetOutput();
   this->template StopCurrentStep<MaskImageType>(output);
+
   //--------------------------------------------------------------------
-  // Step 2: Crop support (previous) to bones extend in AP
+  // Step : Crop support (previous) to bones extend in AP
   if (GetUseBones()) {
-    StartNewStep("Crop support like bones along AP");
+    this->StartNewStep("[Mediastinum] Crop support like bones along AP");
     cropFilter = CropFilterType::New();
     cropFilter->SetInput(output);
     cropFilter->SetCropLikeImage(bones, 1);// Indicate that we only crop in Y (Ant-Post) axe
@@ -195,8 +209,8 @@ GenerateOutputInformation() {
   }
 
   //--------------------------------------------------------------------
-  // Step 3: patient minus lungs, minus bones, minus trachea
-  StartNewStep("Patient contours minus lungs, trachea [and bones]");
+  // Step : patient minus lungs, minus bones, minus trachea
+  this->StartNewStep("[Mediastinum] Patient contours minus lungs, trachea [and bones]");
   typedef clitk::BooleanOperatorLabelImageFilter<MaskImageType> BoolFilterType;
   typename BoolFilterType::Pointer boolFilter = BoolFilterType::New(); 
   boolFilter->InPlaceOn();
@@ -217,70 +231,60 @@ GenerateOutputInformation() {
   output = boolFilter->GetOutput();
 
   // Auto crop to gain support area
-  output = clitk::AutoCrop<MaskImageType>(output, GetBackgroundValue()); 
+  output = clitk::AutoCrop<MaskImageType>(output, this->GetBackgroundValue()); 
   this->template StopCurrentStep<MaskImageType>(output);
 
   //--------------------------------------------------------------------
-  // Step 4: LR limits from lung (need separate lung ?)
+  // Step : LR limits from lung (need separate lung ?)
   // Get separate lung images to get only the right and left lung
   // (because RelativePositionPropImageFilter only consider fg=1);
   // (label must be '1' because right is greater than left).  (WE DO
   // NOT NEED TO SEPARATE ? )
-  StartNewStep("Left/Right limits with lungs");
+  this->StartNewStep("[Mediastinum] Left/Right limits with lungs");
   
   // The following cannot be "inplace" because mask is the same than input ...
   MaskImagePointer right_lung = 
     clitk::SetBackground<MaskImageType, MaskImageType>(lung, lung, 2, 0, false);
   MaskImagePointer left_lung = 
     clitk::SetBackground<MaskImageType, MaskImageType>(lung, lung, 1, 0, false);
-  right_lung = clitk::ResizeImageLike<MaskImageType>(right_lung, output, GetBackgroundValue());
-  left_lung = clitk::ResizeImageLike<MaskImageType>(left_lung, output, GetBackgroundValue());
-  // writeImage<MaskImageType>(right_lung, "right.mhd");
-  // writeImage<MaskImageType>(left_lung, "left.mhd");
-
-  typedef clitk::AddRelativePositionConstraintToLabelImageFilter<MaskImageType> RelPosFilterType;
-  typename RelPosFilterType::Pointer relPosFilter = RelPosFilterType::New();
-  relPosFilter->SetCurrentStepBaseId(this->GetCurrentStepId());
-  relPosFilter->VerboseStepFlagOff();
-  relPosFilter->WriteStepFlagOff();
-  relPosFilter->SetInput(output); 
-  relPosFilter->SetInputObject(left_lung); 
-  //  relPosFilter->SetInputObject(lung); 
-  relPosFilter->AddOrientationType(RelPosFilterType::AtRightTo); // warning left lung is at right ;)
-  relPosFilter->SetIntermediateSpacing(GetIntermediateSpacing());
-  relPosFilter->SetFuzzyThreshold(GetFuzzyThreshold1());
-  relPosFilter->Update();
-  output = relPosFilter->GetOutput();
-  //writeImage<MaskImageType>(right_lung, "step4-left.mhd");
-
-  relPosFilter = RelPosFilterType::New();
-  relPosFilter->SetInput(output); 
-  relPosFilter->SetCurrentStepBaseId(this->GetCurrentStepId());
-  relPosFilter->VerboseStepFlagOff();
-  relPosFilter->WriteStepFlagOff();
-  relPosFilter->SetInput(output); 
-  relPosFilter->SetInputObject(right_lung);
-  //relPosFilter->SetInputObject(lung); 
-  relPosFilter->AddOrientationType(RelPosFilterType::AtLeftTo);
-  relPosFilter->SetIntermediateSpacing(GetIntermediateSpacing());
-  relPosFilter->SetFuzzyThreshold(GetFuzzyThreshold1());
-  relPosFilter->Update();   
-  output = relPosFilter->GetOutput();
+  left_lung = clitk::SetBackground<MaskImageType, MaskImageType>(left_lung, left_lung, 2, 1, false);
+  right_lung = clitk::ResizeImageLike<MaskImageType>(right_lung, output, this->GetBackgroundValue());
+  left_lung = clitk::ResizeImageLike<MaskImageType>(left_lung, output, this->GetBackgroundValue());
+  this->GetAFDB()->template SetImage<MaskImageType>("RightLung", "seg/RightLung.mha", 
+                                                    right_lung, true);
+  this->GetAFDB()->template SetImage<MaskImageType>("LeftLung", "seg/LeftLung.mha", 
+                                                    left_lung, true);
+  this->GetAFDB()->Write();
   this->template StopCurrentStep<MaskImageType>(output);
 
   //--------------------------------------------------------------------
-  // Step 5: AP limits from bones
+  // Step : AP limits from bones
   // Separate the bones in the ant-post middle
-  MaskImageConstPointer bones_ant;
-  MaskImageConstPointer bones_post;
-  MaskImagePointType middle_AntPost__position;
+  MaskImagePointer bones_ant;
+  MaskImagePointer bones_post;
+  MaskImagePointType middle_AntPost_position;
+  middle_AntPost_position.Fill(NumericTraits<MaskImagePointType::ValueType>::Zero);
   if (GetUseBones()) { 
-    StartNewStep("Ant/Post limits with bones");
-    middle_AntPost__position[0] = middle_AntPost__position[2] = 0;
-    middle_AntPost__position[1] = bones->GetOrigin()[1]+(bones->GetLargestPossibleRegion().GetSize()[1]*bones->GetSpacing()[1])/2.0;
+    this->StartNewStep("[Mediastinum] Ant/Post limits with bones");
+
+    // To define ant and post part of the bones with a single horizontal line 
     MaskImageIndexType index_bones_middle;
-    bones->TransformPhysicalPointToIndex(middle_AntPost__position, index_bones_middle);
+
+    // Method1: cut in the middle (not optimal)
+    /*
+    middle_AntPost_position[0] = middle_AntPost_position[2] = 0;
+    middle_AntPost_position[1] = bones->GetOrigin()[1]+
+    (bones->GetLargestPossibleRegion().GetSize()[1]*bones->GetSpacing()[1])/2.0;
+    DD(middle_AntPost_position);
+    bones->TransformPhysicalPointToIndex(middle_AntPost_position, index_bones_middle);
+    */
   
+    // Method2: Use VertebralBody, take most ant point
+    MaskImagePointer VertebralBody = this->GetAFDB()->template GetImage<MaskImageType>("VertebralBody");
+    FindExtremaPointInAGivenDirection<MaskImageType>(VertebralBody, this->GetBackgroundValue(), 
+                                                     1, true, middle_AntPost_position);
+    bones->TransformPhysicalPointToIndex(middle_AntPost_position, index_bones_middle);  
+
     // Split bone image first into two parts (ant and post), and crop
     // lateraly to get vertebral 
     typedef itk::RegionOfInterestImageFilter<MaskImageType, MaskImageType> ROIFilterType;
@@ -291,8 +295,8 @@ GenerateOutputInformation() {
     MaskImageIndexType index = region.GetIndex();
     // ANT part
     // crop LR to keep 1/4 center part
-    index[0] = size[0]/4+size[0]/8;
-    size[0] = size[0]/4; 
+    //    index[0] = size[0]/4+size[0]/8;
+    //size[0] = size[0]/4; 
     // crop AP to keep first (ant) part
     size[1] =  index_bones_middle[1]; //size[1]/2.0;
     region.SetSize(size);
@@ -302,7 +306,7 @@ GenerateOutputInformation() {
     roiFilter->ReleaseDataFlagOff();
     roiFilter->Update();
     bones_ant = roiFilter->GetOutput();
-    //    writeImage<MaskImageType>(bones_ant, "b_ant.mhd");
+    //      writeImage<MaskImageType>(bones_ant, "b_ant.mhd");
     // POST part
     roiFilter = ROIFilterType::New();  
     index[1] = bones->GetLargestPossibleRegion().GetIndex()[1] + size[1]-1;
@@ -314,154 +318,69 @@ GenerateOutputInformation() {
     roiFilter->ReleaseDataFlagOff();
     roiFilter->Update();
     bones_post = roiFilter->GetOutput();
-    //    writeImage<MaskImageType>(bones_post, "b_post.mhd");
-
-    // Go ! 
-    relPosFilter->SetCurrentStepNumber(0);
-    relPosFilter->ResetPipeline();// = RelPosFilterType::New();
-    relPosFilter->SetCurrentStepBaseId(this->GetCurrentStepId());
-    relPosFilter->VerboseStepFlagOff();
-    relPosFilter->WriteStepFlagOff();
-    relPosFilter->SetInput(output); 
-    relPosFilter->SetInputObject(bones_post); 
-    relPosFilter->AddOrientationType(RelPosFilterType::AntTo);
-    relPosFilter->SetIntermediateSpacing(GetIntermediateSpacing());
-    relPosFilter->SetFuzzyThreshold(GetFuzzyThreshold2());
-    relPosFilter->Update();
-    output = relPosFilter->GetOutput();
-    //    writeImage<MaskImageType>(output, "post.mhd");
-
-    relPosFilter->SetInput(relPosFilter->GetOutput()); 
-    relPosFilter->SetCurrentStepBaseId(this->GetCurrentStepId());
-    relPosFilter->VerboseStepFlagOff();
-    relPosFilter->WriteStepFlagOff();
-    relPosFilter->SetInput(output); 
-    relPosFilter->SetInputObject(bones_ant); 
-    relPosFilter->AddOrientationType(RelPosFilterType::PostTo);
-    relPosFilter->SetIntermediateSpacing(GetIntermediateSpacing());
-    relPosFilter->SetFuzzyThreshold(GetFuzzyThreshold2());
-    relPosFilter->Update();   
-    output = relPosFilter->GetOutput();
+    // writeImage<MaskImageType>(bones_post, "b_post.mhd");
+
+    // Now, insert this image in the AFDB ==> (needed because used in the RelativePosition config file)
+    this->GetAFDB()->template SetImage<MaskImageType>("Bones_Post", "seg/Bones_Post.mha", 
+                                                 bones_post, true);
+    this->GetAFDB()->template SetImage<MaskImageType>("Bones_Ant", "seg/Bones_Ant.mha", 
+                                                 bones_ant, true);
+    this->GetAFDB()->Write();
+
     this->template StopCurrentStep<MaskImageType>(output);
   }
 
   //--------------------------------------------------------------------
-  // Step 6: Get CCL
-  StartNewStep("Keep main connected component");
-  output = clitk::Labelize<MaskImageType>(output, GetBackgroundValue(), false, 500);
-  // output = RemoveLabels<MaskImageType>(output, BG, param->GetLabelsToRemove());
-  output = clitk::KeepLabels<MaskImageType>(output, GetBackgroundValue(), 
-                                            GetForegroundValue(), 1, 1, 0);
+  // Remove VertebralBody part
+  this->StartNewStep("[Mediastinum] Remove VertebralBody");  
+  MaskImagePointer VertebralBody = this->GetAFDB()->template GetImage<MaskImageType>("VertebralBody");
+  clitk::AndNot<MaskImageType>(output, VertebralBody, this->GetBackgroundValue());
   this->template StopCurrentStep<MaskImageType>(output);
 
-
   //--------------------------------------------------------------------
-  // Step 8: Trial segmentation KMeans
-  if (0) {
-    StartNewStep("K means");
-    // Take input, crop like current mask
-    typedef CropLikeImageFilter<ImageType> CropLikeFilterType;
-    typename CropLikeFilterType::Pointer cropLikeFilter = CropLikeFilterType::New();
-    cropLikeFilter->SetInput(input);
-    cropLikeFilter->SetCropLikeImage(output);
-    cropLikeFilter->Update();
-    ImagePointer working_input = cropLikeFilter->GetOutput();
-    writeImage<ImageType>(working_input, "crop-input.mhd");
-    // Set bG at -1000
-    working_input = clitk::SetBackground<ImageType, MaskImageType>(working_input, output, GetBackgroundValue(), -1000, true);
-    writeImage<ImageType>(working_input, "crop-input2.mhd");
-    // Kmeans
-    typedef itk::ScalarImageKmeansImageFilter<ImageType> KMeansFilterType;
-    typename KMeansFilterType::Pointer kmeansFilter = KMeansFilterType::New();
-    kmeansFilter->SetInput(working_input);
-    //  const unsigned int numberOfInitialClasses = 3;
-    // const unsigned int useNonContiguousLabels = 0;
-    kmeansFilter->AddClassWithInitialMean(-1000);
-    kmeansFilter->AddClassWithInitialMean(30);
-    kmeansFilter->AddClassWithInitialMean(-40);  // ==> I want this one
-    DD("Go!");
-    kmeansFilter->Update();
-    DD("End");
-    typename KMeansFilterType::ParametersType estimatedMeans = kmeansFilter->GetFinalMeans();
-    const unsigned int numberOfClasses = estimatedMeans.Size();
-    for ( unsigned int i = 0 ; i < numberOfClasses ; ++i ) {
-      std::cout << "cluster[" << i << "] ";
-      std::cout << "    estimated mean : " << estimatedMeans[i] << std::endl;
-    }
-    MaskImageType::Pointer kmeans = kmeansFilter->GetOutput();
-    kmeans = clitk::SetBackground<MaskImageType, MaskImageType>(kmeans, kmeans, 
-                                                                1, GetBackgroundValue(), true);
-    writeImage<MaskImageType>(kmeans, "kmeans.mhd");
-    // Get final results, and remove from current mask
-    boolFilter = BoolFilterType::New(); 
-    boolFilter->InPlaceOn();
-    boolFilter->SetInput1(output);
-    boolFilter->SetInput2(kmeans);    
-    boolFilter->SetOperationType(BoolFilterType::And);
-    boolFilter->Update();    
-    output = boolFilter->GetOutput();
-    writeImage<MaskImageType>(output, "out-kmean.mhd");
-    this->template StopCurrentStep<MaskImageType>(output);
-
-    // TODO -> FillMASK ?
-    // comment speed ? mask ? 2 class ?
-
+  // Generic RelativePosition processes
+  output = this->ApplyRelativePositionList("Mediastinum", output);
 
-    //TODO 
-    // Confidence connected ?
 
+  //--------------------------------------------------------------------
+  // FIXME --> do not put this limits here !
+  /*
+  // Step : SI limits It is better to do this limit *AFTER* the
+  // RelativePosition to avoid some issue due to superior boundaries.
+  this->StartNewStep("[Mediastinum] Keep inferior to CricoidCartilag");
+  // load Cricoid, get centroid, cut above (or below), lower bound
+  MaskImagePointType p;
+  try {
+    MaskImagePointer CricoidCartilag = this->GetAFDB()->template GetImage <MaskImageType>("CricoidCartilag");
+    p[0] = p[1] = p[2] =  0.0; // to avoid warning
+    clitk::FindExtremaPointInAGivenDirection<MaskImageType>(CricoidCartilag, 
+                                                            this->GetBackgroundValue(), 2, true, p);
+  } catch (clitk::ExceptionObject e) {
+    //DD("CricoidCartilag image not found, try CricoidCartilagZ");
+    this->GetAFDB()->GetPoint3D("CricoidCartilagPoint", p);
   }
+  output = clitk::CropImageRemoveGreaterThan<MaskImageType>(output, 2, p[2], true, this->GetBackgroundValue());
+  this->template StopCurrentStep<MaskImageType>(output);
+  */
 
   //--------------------------------------------------------------------
-  // Step 8: Lower limits from lung (need separate lung ?)
-  if (0) {
-    // StartNewStep("Trial : minus segmented struct");
-    // MaskImagePointer heart = GetAFDB()->template GetImage <MaskImageType>("heart");  
-    // boolFilter = BoolFilterType::New(); 
-    // boolFilter->InPlaceOn();
-    // boolFilter->SetInput1(output);
-    // boolFilter->SetInput2(heart);
-    // boolFilter->SetOperationType(BoolFilterType::AndNot);
-    // boolFilter->Update();  
-    //  output = boolFilter->GetOutput(); // not needed because InPlace
-    
-    // Not below the heart
-    // relPosFilter = RelPosFilterType::New();
-    // relPosFilter->SetCurrentStepBaseId(this->GetCurrentStepId());
-    // relPosFilter->VerboseStepFlagOff();
-    // relPosFilter->WriteStepFlagOff();
-    // relPosFilter->SetInput(output); 
-    // relPosFilter->SetInputObject(heart);
-    // relPosFilter->SetOrientationType(RelPosFilterType::SupTo);
-    // relPosFilter->SetIntermediateSpacing(GetIntermediateSpacing());
-    // relPosFilter->SetFuzzyThreshold(GetFuzzyThreshold3());
-    // relPosFilter->Update();
-    // output = relPosFilter->GetOutput();
-  }
+  // Step: Get CCL
+  this->StartNewStep("[Mediastinum] Keep main connected component");
+  output = clitk::Labelize<MaskImageType>(output, this->GetBackgroundValue(), false, 500);
+  // output = RemoveLabels<MaskImageType>(output, BG, param->GetLabelsToRemove());
+  output = clitk::KeepLabels<MaskImageType>(output, this->GetBackgroundValue(), 
+                                            this->GetForegroundValue(), 1, 1, 0);
+  this->template StopCurrentStep<MaskImageType>(output);
 
   //--------------------------------------------------------------------
-  // Step 8: Lower limits from lung (need separate lung ?)
-  if (0) {
-    StartNewStep("Lower limits with lungs");
-    // TODO BOFFF ????
-    relPosFilter = RelPosFilterType::New();
-    relPosFilter->SetCurrentStepBaseId(this->GetCurrentStepId());
-    relPosFilter->VerboseStepFlagOff();
-    relPosFilter->WriteStepFlagOff();
-    relPosFilter->SetInput(output); 
-    //  relPosFilter->SetInputObject(left_lung); 
-    relPosFilter->SetInputObject(lung); 
-    relPosFilter->AddOrientationType(RelPosFilterType::SupTo);
-    relPosFilter->SetIntermediateSpacing(GetIntermediateSpacing());
-    relPosFilter->SetFuzzyThreshold(GetFuzzyThreshold3());
-    relPosFilter->Update();
-    output = relPosFilter->GetOutput();
-    this->template StopCurrentStep<MaskImageType>(output);
-  }
+  // Step: Remove post part from VertebralBody
+  this->StartNewStep("[Mediastinum] Remove post part according to VertebralBody");
+  RemovePostPartOfVertebralBody();
+  this->template StopCurrentStep<MaskImageType>(output);
 
   //--------------------------------------------------------------------
-  // Step 10: Slice by Slice CCL
-  StartNewStep("Slice by Slice keep only one component");
+  // Step: Slice by Slice CCL
+  this->StartNewStep("[Mediastinum] Slice by Slice keep only one component");
   typedef clitk::ExtractSliceFilter<MaskImageType> ExtractSliceFilterType;
   //  typename ExtractSliceFilterType::Pointer 
   ExtractSliceFilterType::Pointer extractSliceFilter = ExtractSliceFilterType::New();
@@ -486,59 +405,12 @@ GenerateOutputInformation() {
   output = joinFilter->GetOutput();
   this->template StopCurrentStep<MaskImageType>(output);
 
-  //--------------------------------------------------------------------
-  // Step 9: Binarize to remove too high HU
-  // --> warning CCL slice by slice must be done before
-  if (0) {
-    StartNewStep("Remove hypersignal (bones and injected part");
-    // Crop initial ct like current support
-    typedef CropLikeImageFilter<ImageType> CropLikeFilterType;
-    typename CropLikeFilterType::Pointer cropLikeFilter = CropLikeFilterType::New();
-    cropLikeFilter->SetInput(input);
-    cropLikeFilter->SetCropLikeImage(output);
-    cropLikeFilter->Update();
-    ImagePointer working_input = cropLikeFilter->GetOutput();
-    //  writeImage<ImageType>(working_input, "crop-ct.mhd");
-    // Binarize
-    typedef itk::BinaryThresholdImageFilter<ImageType, MaskImageType> InputBinarizeFilterType; 
-    typename InputBinarizeFilterType::Pointer binarizeFilter=InputBinarizeFilterType::New();
-    binarizeFilter->SetInput(working_input);
-    binarizeFilter->SetLowerThreshold(GetLowerThreshold());
-    binarizeFilter->SetUpperThreshold(GetUpperThreshold());
-    binarizeFilter->SetInsideValue(this->GetBackgroundValue());  // opposite
-    binarizeFilter->SetOutsideValue(this->GetForegroundValue()); // opposite
-    binarizeFilter->Update();
-    MaskImagePointer working_bin = binarizeFilter->GetOutput();
-    // writeImage<MaskImageType>(working_bin, "bin.mhd");
-    // Remove from support
-    boolFilter = BoolFilterType::New(); 
-    boolFilter->InPlaceOn();
-    boolFilter->SetInput1(output);
-    boolFilter->SetInput2(working_bin);    
-    boolFilter->SetOperationType(BoolFilterType::AndNot);
-    boolFilter->Update();
-    output = boolFilter->GetOutput();
-    StopCurrentStep<MaskImageType>(output);
-  }
-
   //--------------------------------------------------------------------
   // Step 10 : AutoCrop
-  StartNewStep("AutoCrop");
-  output = clitk::AutoCrop<MaskImageType>(output, GetBackgroundValue()); 
+  this->StartNewStep("[Mediastinum] AutoCrop");
+  output = clitk::AutoCrop<MaskImageType>(output, this->GetBackgroundValue()); 
   this->template StopCurrentStep<MaskImageType>(output);
 
-  // Bones ? pb with RAM ? FillHoles ?
-
-  // how to do with post part ? spine /lung ?
-  // POST the spine (should be separated from the rest) 
-  /// DO THAT ---->>
-  // histo Y on the whole bones_post (3D) -> result is the Y center on the spine (?)
-  // by slice on bones_post
-  //       find the most ant point in the center
-  //       from this point go to post until out of bones.
-  //       
-
-
   // End, set the real size
   this->GetOutput(0)->SetRegions(output->GetLargestPossibleRegion());
   this->GetOutput(0)->SetLargestPossibleRegion(output->GetLargestPossibleRegion());
@@ -556,10 +428,106 @@ GenerateData()
 {
   this->GraftOutput(output);
   // Store image filenames into AFDB 
-  GetAFDB()->SetImageFilename("Mediastinum", this->GetOutputMediastinumFilename());  
-  WriteAFDB();
+  this->GetAFDB()->SetImageFilename("Mediastinum", this->GetOutputMediastinumFilename());  
+  this->WriteAFDB();
 }
 //--------------------------------------------------------------------
+
   
+//--------------------------------------------------------------------
+template <class ImageType>
+void 
+clitk::ExtractMediastinumFilter<ImageType>::
+RemovePostPartOfVertebralBody()
+{
+  
+  /*
+    Posteriorly, Station 8 abuts the descending aorta and the anterior
+    aspect of the vertebral body until an imaginary horizontal line
+    running 1 cm posterior to the anterior border of the vertebral
+    body (Fig. 3C).
+    
+    => We use this definition for all the mediastinum
+
+   Find most Ant point in VertebralBody. Consider the horizontal line
+   which is 'DistanceMaxToAnteriorPartOfTheVertebralBody' away from
+   the most ant point.
+  */
+
+  // Get VertebralBody mask image
+  MaskImagePointer VertebralBody = 
+    this->GetAFDB()->template GetImage <MaskImageType>("VertebralBody");  
+
+  // Consider vertebral body slice by slice
+  std::vector<MaskSlicePointer> vertebralSlices;
+  clitk::ExtractSlices<MaskImageType>(VertebralBody, 2, vertebralSlices);
+
+  // For each slice, compute the most anterior point
+  std::map<int, MaskSlicePointType> vertebralAntPositionBySlice;
+  for(uint i=0; i<vertebralSlices.size(); i++) {
+    MaskSlicePointType p;
+    bool found = clitk::FindExtremaPointInAGivenDirection<MaskSliceType>(vertebralSlices[i], 
+                                                                     this->GetBackgroundValue(), 
+                                                                     1, true, p);
+    if (found) {
+      vertebralAntPositionBySlice[i] = p;
+    }
+    else { 
+      // It should not happen ! But sometimes, a contour is missing or
+      // the VertebralBody is not delineated enough inferiorly ... in
+      // those cases, we consider the first found slice.
+      //        std::cerr << "No foreground pixels in this VertebralBody slices !?? I try with the previous/next slice" << std::endl;
+      // [ Possible alternative -> consider previous limit ]
+    }
+  }
+
+  // Convert 2D points in slice into 3D points
+  std::vector<MaskImagePointType> vertebralAntPositions;
+  clitk::PointsUtils<MaskImageType>::Convert2DMapTo3DList(vertebralAntPositionBySlice, 
+                                                          VertebralBody, 
+                                                          vertebralAntPositions);
+
+  // DEBUG : write list of points
+  clitk::WriteListOfLandmarks<MaskImageType>(vertebralAntPositions, 
+                                             "VertebralBodyMostAnteriorPoints.txt");
+
+  // Cut support posteriorly 1cm the most anterior point of the
+  // VertebralBody. Do nothing below and above the VertebralBody. To
+  // do that compute several region, slice by slice and fill. 
+  MaskImageRegionType region;
+  MaskImageSizeType size;
+  MaskImageIndexType start;
+  size[2] = 1; // a single slice
+  start[0] = output->GetLargestPossibleRegion().GetIndex()[0];
+  size[0] = output->GetLargestPossibleRegion().GetSize()[0];
+  for(uint i=0; i<vertebralAntPositions.size(); i++) {
+    typedef typename itk::ImageRegionIterator<MaskImageType> IteratorType;
+    IteratorType iter = 
+      IteratorType(output, output->GetLargestPossibleRegion());
+    MaskImageIndexType index;
+    // Consider some cm posterior to most anterior positions (usually
+    // 1 cm).
+    vertebralAntPositions[i][1] += GetDistanceMaxToAnteriorPartOfTheVertebralBody();
+    // Get index of this point
+    output->TransformPhysicalPointToIndex(vertebralAntPositions[i], index);
+    // Compute region (a single slice)
+    start[2] = index[2];
+    start[1] = output->GetLargestPossibleRegion().GetIndex()[1]+index[1];
+    size[1] = output->GetLargestPossibleRegion().GetSize()[1]-start[1];
+    region.SetSize(size);
+    region.SetIndex(start);
+    // Fill region
+    if (output->GetLargestPossibleRegion().IsInside(start))  {
+      itk::ImageRegionIterator<MaskImageType> it(output, region);
+      it.GoToBegin();
+      while (!it.IsAtEnd()) {
+        it.Set(this->GetBackgroundValue());
+        ++it;
+      }
+    }
+  }  
+}
+//--------------------------------------------------------------------
+
 
 #endif //#define CLITKBOOLEANOPERATORLABELIMAGEFILTER_TXX