1 /*=========================================================================
2 Program: vv http://www.creatis.insa-lyon.fr/rio/vv
5 - University of LYON http://www.universite-lyon.fr/
6 - Léon Bérard cancer center http://www.centreleonberard.fr
7 - CREATIS CNRS laboratory http://www.creatis.insa-lyon.fr
9 This software is distributed WITHOUT ANY WARRANTY; without even
10 the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR
11 PURPOSE. See the copyright notices for more information.
13 It is distributed under dual licence
15 - BSD See included LICENSE.txt file
16 - CeCILL-B http://www.cecill.info/licences/Licence_CeCILL-B_V1-en.html
17 ===========================================================================**/
18 #ifndef clitkBLUTDIRGenericFilter_cxx
19 #define clitkBLUTDIRGenericFilter_cxx
21 /* =================================================
22 * @file clitkBLUTDIRGenericFilter.cxx
28 ===================================================*/
30 #include "clitkBLUTDIRGenericFilter.h"
31 #include "clitkBLUTDIRCommandIterationUpdateDVF.h"
32 #include "itkCenteredTransformInitializer.h"
33 #if ITK_VERSION_MAJOR >= 4
34 # if ITK_VERSION_MINOR < 6
35 # include "itkTransformToDisplacementFieldSource.h"
37 # include "itkTransformToDisplacementFieldFilter.h"
40 # include "itkTransformToDeformationFieldSource.h"
46 //==============================================================================
47 // Creating an observer class that allows output at each iteration
48 //==============================================================================
49 class CommandIterationUpdate : public itk::Command
52 typedef CommandIterationUpdate Self;
53 typedef itk::Command Superclass;
54 typedef itk::SmartPointer<Self> Pointer;
57 CommandIterationUpdate() {};
59 typedef clitk::GenericOptimizer<args_info_clitkBLUTDIR> OptimizerType;
60 typedef const OptimizerType * OptimizerPointer;
62 // Set the generic optimizer
63 void SetOptimizer(OptimizerPointer o){m_Optimizer=o;}
66 void Execute(itk::Object *caller, const itk::EventObject & event)
68 Execute( (const itk::Object *)caller, event);
71 void Execute(const itk::Object * object, const itk::EventObject & event)
73 if( !(itk::IterationEvent().CheckEvent( &event )) )
78 m_Optimizer->OutputIterationInfo();
81 OptimizerPointer m_Optimizer;
84 //===========================================================================//
86 //==========================================================================//
87 BLUTDIRGenericFilter::BLUTDIRGenericFilter():
88 ImageToImageGenericFilter<Self>("Register DIR")
90 InitializeImageType<2>();
91 InitializeImageType<3>();
95 //=========================================================================//
97 //==========================================================================//
98 void BLUTDIRGenericFilter::SetArgsInfo(const args_info_clitkBLUTDIR & a){
100 if (m_ArgsInfo.reference_given) AddInputFilename(m_ArgsInfo.reference_arg);
102 if (m_ArgsInfo.target_given) {
103 AddInputFilename(m_ArgsInfo.target_arg);
106 if (m_ArgsInfo.output_given) SetOutputFilename(m_ArgsInfo.output_arg);
108 if (m_ArgsInfo.verbose_given) m_Verbose=true;
111 //=========================================================================//
112 //===========================================================================//
113 template<unsigned int Dim>
114 void BLUTDIRGenericFilter::InitializeImageType()
116 ADD_DEFAULT_IMAGE_TYPES(3);
118 //--------------------------------------------------------------------
120 //==============================================================================
121 //Creating an observer class that allows us to change parameters at subsequent levels
122 //==============================================================================
123 template <typename TRegistration,class args_info_clitkBLUTDIR>
124 class RegistrationInterfaceCommand : public itk::Command
127 typedef RegistrationInterfaceCommand Self;
128 typedef itk::Command Superclass;
129 typedef itk::SmartPointer<Self> Pointer;
132 RegistrationInterfaceCommand() { };
136 typedef TRegistration RegistrationType;
137 typedef RegistrationType * RegistrationPointer;
140 typedef typename RegistrationType::FixedImageType FixedImageType;
141 typedef typename FixedImageType::RegionType RegionType;
142 itkStaticConstMacro(ImageDimension, unsigned int,FixedImageType::ImageDimension);
143 typedef clitk::MultipleBSplineDeformableTransform<double, ImageDimension, ImageDimension> TransformType;
144 typedef clitk::MultipleBSplineDeformableTransformInitializer<TransformType, FixedImageType> InitializerType;
145 typedef typename InitializerType::CoefficientImageType CoefficientImageType;
146 typedef itk::CastImageFilter<CoefficientImageType, CoefficientImageType> CastImageFilterType;
147 typedef typename TransformType::ParametersType ParametersType;
148 typedef typename InitializerType::Pointer InitializerPointer;
149 typedef CommandIterationUpdate::Pointer CommandIterationUpdatePointer;
152 typedef clitk::GenericOptimizer<args_info_clitkBLUTDIR> GenericOptimizerType;
153 typedef typename GenericOptimizerType::Pointer GenericOptimizerPointer;
156 typedef typename RegistrationType::FixedImageType InternalImageType;
157 typedef clitk::GenericMetric<args_info_clitkBLUTDIR, InternalImageType, InternalImageType> GenericMetricType;
158 typedef typename GenericMetricType::Pointer GenericMetricPointer;
160 // Two arguments are passed to the Execute() method: the first
161 // is the pointer to the object which invoked the event and the
162 // second is the event that was invoked.
163 void Execute(itk::Object * object, const itk::EventObject & event)
165 if( !(itk::IterationEvent().CheckEvent( &event )) )
171 RegistrationPointer registration = dynamic_cast<RegistrationPointer>( object );
172 unsigned int numberOfLevels=registration->GetNumberOfLevels();
173 unsigned int currentLevel=registration->GetCurrentLevel()+1;
176 std::cout<<std::endl;
177 std::cout<<"========================================"<<std::endl;
178 std::cout<<"Starting resolution level "<<currentLevel<<" of "<<numberOfLevels<<"..."<<std::endl;
179 std::cout<<"========================================"<<std::endl;
180 std::cout<<std::endl;
185 // fixed image region pyramid
186 typedef clitk::MultiResolutionPyramidRegionFilter<InternalImageType> FixedImageRegionPyramidType;
187 typename FixedImageRegionPyramidType::Pointer fixedImageRegionPyramid=FixedImageRegionPyramidType::New();
188 fixedImageRegionPyramid->SetRegion(m_MetricRegion);
189 fixedImageRegionPyramid->SetSchedule(registration->GetFixedImagePyramid()->GetSchedule());
191 // Reinitialize the metric (!= number of samples)
192 m_GenericMetric= GenericMetricType::New();
193 m_GenericMetric->SetArgsInfo(m_ArgsInfo);
194 m_GenericMetric->SetFixedImage(registration->GetFixedImagePyramid()->GetOutput(registration->GetCurrentLevel()));
195 if (m_ArgsInfo.referenceMask_given) m_GenericMetric->SetFixedImageMask(registration->GetMetric()->GetFixedImageMask());
196 m_GenericMetric->SetFixedImageRegion(fixedImageRegionPyramid->GetOutput(registration->GetCurrentLevel()));
197 typedef itk::ImageToImageMetric< InternalImageType, InternalImageType > MetricType;
198 typename MetricType::Pointer metric=m_GenericMetric->GetMetricPointer();
199 registration->SetMetric(metric);
201 // Get the current coefficient image and make a COPY
202 typename itk::ImageDuplicator<CoefficientImageType>::Pointer caster = itk::ImageDuplicator<CoefficientImageType>::New();
203 std::vector<typename CoefficientImageType::Pointer> currentCoefficientImages = m_Initializer->GetTransform()->GetCoefficientImages();
204 for (unsigned i = 0; i < currentCoefficientImages.size(); ++i)
206 caster->SetInputImage(currentCoefficientImages[i]);
208 currentCoefficientImages[i] = caster->GetOutput();
212 // Write the intermediate result?
213 if (m_ArgsInfo.intermediate_given>=numberOfLevels)
214 writeImage<CoefficientImageType>(currentCoefficientImage, m_ArgsInfo.intermediate_arg[currentLevel-2], m_ArgsInfo.verbose_flag);
217 // Set the new transform properties
218 m_Initializer->SetImage(registration->GetFixedImagePyramid()->GetOutput(currentLevel-1));
219 if( m_Initializer->m_ControlPointSpacingIsGiven)
220 m_Initializer->SetControlPointSpacing(m_Initializer->m_ControlPointSpacingArray[registration->GetCurrentLevel()]);
221 if( m_Initializer->m_NumberOfControlPointsIsGiven)
222 m_Initializer->SetNumberOfControlPointsInsideTheImage(m_Initializer->m_NumberOfControlPointsInsideTheImageArray[registration->GetCurrentLevel()]);
224 // Reinitialize the transform
225 if (m_ArgsInfo.verbose_flag) std::cout<<"Initializing transform for level "<<currentLevel<<" of "<<numberOfLevels<<"..."<<std::endl;
226 m_Initializer->InitializeTransform();
227 ParametersType* newParameters= new typename TransformType::ParametersType(m_Initializer->GetTransform()->GetNumberOfParameters());
229 // DS : if we want to skip the last pyramid level, force to only 1 iteration
230 DD(m_ArgsInfo.skipLastPyramidLevel_flag);
231 if ((currentLevel == numberOfLevels) && (m_ArgsInfo.skipLastPyramidLevel_flag)) {
232 DD(m_ArgsInfo.maxIt_arg);
233 std::cout << "I skip the last pyramid level : set max iteration to 0" << std::endl;
234 m_ArgsInfo.maxIt_arg = 0;
235 DD(m_ArgsInfo.maxIt_arg);
238 // Reinitialize an Optimizer (!= number of parameters)
239 m_GenericOptimizer = GenericOptimizerType::New();
240 m_GenericOptimizer->SetArgsInfo(m_ArgsInfo);
241 m_GenericOptimizer->SetMaximize(m_Maximize);
242 m_GenericOptimizer->SetNumberOfParameters(m_Initializer->GetTransform()->GetNumberOfParameters());
245 typedef itk::SingleValuedNonLinearOptimizer OptimizerType;
246 OptimizerType::Pointer optimizer = m_GenericOptimizer->GetOptimizerPointer();
247 optimizer->AddObserver( itk::IterationEvent(), m_CommandIterationUpdate);
248 registration->SetOptimizer(optimizer);
249 m_CommandIterationUpdate->SetOptimizer(m_GenericOptimizer);
251 // Set the previous transform parameters to the registration
252 // if(m_Initializer->m_Parameters!=NULL )delete m_Initializer->m_Parameters;
253 m_Initializer->SetInitialParameters(currentCoefficientImages, *newParameters);
254 registration->SetInitialTransformParametersOfNextLevel(*newParameters);
258 void Execute(const itk::Object * , const itk::EventObject & )
263 void SetInitializer(InitializerPointer i){m_Initializer=i;}
264 InitializerPointer m_Initializer;
266 void SetArgsInfo(args_info_clitkBLUTDIR a){m_ArgsInfo=a;}
267 args_info_clitkBLUTDIR m_ArgsInfo;
269 void SetCommandIterationUpdate(CommandIterationUpdatePointer c){m_CommandIterationUpdate=c;};
270 CommandIterationUpdatePointer m_CommandIterationUpdate;
272 GenericOptimizerPointer m_GenericOptimizer;
273 void SetMaximize(bool b){m_Maximize=b;}
276 GenericMetricPointer m_GenericMetric;
277 void SetMetricRegion(RegionType i){m_MetricRegion=i;}
278 RegionType m_MetricRegion;
283 //==============================================================================
284 // Update with the number of dimensions and pixeltype
285 //==============================================================================
286 template<class InputImageType>
287 void BLUTDIRGenericFilter::UpdateWithInputImageType()
289 if (m_Verbose) std::cout << "BLUTDIRGenericFilter::UpdateWithInputImageType()" << std::endl;
291 //=============================================================================
293 //=============================================================================
294 bool threadsGiven=m_ArgsInfo.threads_given;
295 int threads=m_ArgsInfo.threads_arg;
296 typedef typename InputImageType::PixelType PixelType;
298 typedef double TCoordRep;
300 typename InputImageType::Pointer fixedImage = this->template GetInput<InputImageType>(0);
302 typename InputImageType::Pointer inputFixedImage = this->template GetInput<InputImageType>(0);
305 typename InputImageType::Pointer movingImage = this->template GetInput<InputImageType>(1);
307 typename InputImageType::Pointer inputMovingImage = this->template GetInput<InputImageType>(1);
309 typedef itk::Image< PixelType,InputImageType::ImageDimension > FixedImageType;
310 typedef itk::Image< PixelType, InputImageType::ImageDimension> MovingImageType;
311 const unsigned int SpaceDimension = InputImageType::ImageDimension;
312 //Whatever the pixel type, internally we work with an image represented in float
313 //Reading reference image
314 if (m_Verbose) std::cout<<"Reading images..."<<std::endl;
315 //=======================================================
317 //=======================================================
318 typename FixedImageType::Pointer croppedFixedImage=fixedImage;
319 //=======================================================
321 //=======================================================
322 // The original input region
323 typename FixedImageType::RegionType fixedImageRegion = fixedImage->GetLargestPossibleRegion();
325 // The transform region with respect to the input region:
326 // where should the transform be DEFINED (depends on mask)
327 typename FixedImageType::RegionType transformRegion = fixedImage->GetLargestPossibleRegion();
328 typename FixedImageType::RegionType::SizeType transformRegionSize=transformRegion.GetSize();
329 typename FixedImageType::RegionType::IndexType transformRegionIndex=transformRegion.GetIndex();
330 typename FixedImageType::PointType transformRegionOrigin=fixedImage->GetOrigin();
332 // The metric region with respect to the extracted transform region:
333 // where should the metric be CALCULATED (depends on transform)
334 typename FixedImageType::RegionType metricRegion = fixedImage->GetLargestPossibleRegion();
335 typename FixedImageType::RegionType::IndexType metricRegionIndex=metricRegion.GetIndex();
336 typename FixedImageType::PointType metricRegionOrigin=fixedImage->GetOrigin();
339 //===========================================================================
340 // If given, we connect a mask to reference or target
341 //============================================================================
342 typedef itk::ImageMaskSpatialObject< InputImageType::ImageDimension > MaskType;
343 typedef itk::Image< unsigned char, InputImageType::ImageDimension > ImageLabelType;
344 typename MaskType::Pointer fixedMask = NULL;
345 typename ImageLabelType::Pointer labels = NULL;
346 if (m_ArgsInfo.referenceMask_given)
348 fixedMask = MaskType::New();
349 labels = ImageLabelType::New();
350 typedef itk::ImageFileReader< ImageLabelType > LabelReaderType;
351 typename LabelReaderType::Pointer labelReader = LabelReaderType::New();
352 labelReader->SetFileName(m_ArgsInfo.referenceMask_arg);
355 labelReader->Update();
357 catch( itk::ExceptionObject & err )
359 std::cerr << "ExceptionObject caught while reading mask or labels !" << std::endl;
360 std::cerr << err << std::endl;
363 if (m_Verbose)std::cout <<"Reference image mask was read..." <<std::endl;
366 typedef itk::ResampleImageFilter<ImageLabelType, ImageLabelType> ResamplerType;
367 typename ResamplerType::Pointer resampler = ResamplerType::New();
368 typedef itk::NearestNeighborInterpolateImageFunction<ImageLabelType, TCoordRep> InterpolatorType;
369 typename InterpolatorType::Pointer interpolator = InterpolatorType::New();
370 resampler->SetOutputParametersFromImage(fixedImage);
371 resampler->SetInterpolator(interpolator);
372 resampler->SetInput(labelReader->GetOutput());
374 labels = resampler->GetOutput();
376 // Set the image to the spatialObject
377 fixedMask->SetImage(labels);
379 // Find the bounding box of the "inside" label
380 typedef itk::LabelGeometryImageFilter<ImageLabelType> GeometryImageFilterType;
381 typename GeometryImageFilterType::Pointer geometryImageFilter=GeometryImageFilterType::New();
382 geometryImageFilter->SetInput(labels);
383 geometryImageFilter->Update();
384 typename GeometryImageFilterType::BoundingBoxType boundingBox = geometryImageFilter->GetBoundingBox(1);
386 // Limit the transform region to the mask
387 for (unsigned int i=0; i<InputImageType::ImageDimension; i++)
389 transformRegionIndex[i]=boundingBox[2*i];
390 transformRegionSize[i]=boundingBox[2*i+1]-boundingBox[2*i]+1;
392 transformRegion.SetSize(transformRegionSize);
393 transformRegion.SetIndex(transformRegionIndex);
394 fixedImage->TransformIndexToPhysicalPoint(transformRegion.GetIndex(), transformRegionOrigin);
396 // Crop the fixedImage to the bounding box to facilitate multi-resolution
397 typedef itk::ExtractImageFilter<FixedImageType,FixedImageType> ExtractImageFilterType;
398 typename ExtractImageFilterType::Pointer extractImageFilter=ExtractImageFilterType::New();
399 extractImageFilter->SetDirectionCollapseToSubmatrix();
400 extractImageFilter->SetInput(fixedImage);
401 extractImageFilter->SetExtractionRegion(transformRegion);
402 extractImageFilter->Update();
403 croppedFixedImage=extractImageFilter->GetOutput();
405 // Update the metric region
406 metricRegion = croppedFixedImage->GetLargestPossibleRegion();
407 metricRegionIndex=metricRegion.GetIndex();
408 croppedFixedImage->TransformIndexToPhysicalPoint(metricRegionIndex, metricRegionOrigin);
410 // Set start index to zero (with respect to croppedFixedImage/transform region)
411 metricRegionIndex.Fill(0);
412 metricRegion.SetIndex(metricRegionIndex);
413 croppedFixedImage->SetRegions(metricRegion);
414 croppedFixedImage->SetOrigin(metricRegionOrigin);
417 typedef itk::ImageMaskSpatialObject< InputImageType::ImageDimension > MaskType;
418 typename MaskType::Pointer movingMask=NULL;
419 if (m_ArgsInfo.targetMask_given)
421 movingMask= MaskType::New();
422 typedef itk::Image< unsigned char, InputImageType::ImageDimension > ImageMaskType;
423 typedef itk::ImageFileReader< ImageMaskType > MaskReaderType;
424 typename MaskReaderType::Pointer maskReader = MaskReaderType::New();
425 maskReader->SetFileName(m_ArgsInfo.targetMask_arg);
428 maskReader->Update();
430 catch( itk::ExceptionObject & err )
432 std::cerr << "ExceptionObject caught !" << std::endl;
433 std::cerr << err << std::endl;
435 if (m_Verbose)std::cout <<"Target image mask was read..." <<std::endl;
437 movingMask->SetImage( maskReader->GetOutput() );
441 //=======================================================
443 //=======================================================
447 // Fixed image region
448 std::cout<<"The fixed image has its origin at "<<fixedImage->GetOrigin()<<std::endl
449 <<"The fixed image region starts at index "<<fixedImageRegion.GetIndex()<<std::endl
450 <<"The fixed image region has size "<< fixedImageRegion.GetSize()<<std::endl;
453 std::cout<<"The transform has its origin at "<<transformRegionOrigin<<std::endl
454 <<"The transform region will start at index "<<transformRegion.GetIndex()<<std::endl
455 <<"The transform region has size "<< transformRegion.GetSize()<<std::endl;
458 std::cout<<"The metric region has its origin at "<<metricRegionOrigin<<std::endl
459 <<"The metric region will start at index "<<metricRegion.GetIndex()<<std::endl
460 <<"The metric region has size "<< metricRegion.GetSize()<<std::endl;
465 //=======================================================
466 // Pyramids (update them for transform initializer)
467 //=======================================================
468 typedef itk::RecursiveMultiResolutionPyramidImageFilter< FixedImageType, FixedImageType> FixedImagePyramidType;
469 typedef itk::RecursiveMultiResolutionPyramidImageFilter< MovingImageType, MovingImageType> MovingImagePyramidType;
470 typename FixedImagePyramidType::Pointer fixedImagePyramid = FixedImagePyramidType::New();
471 typename MovingImagePyramidType::Pointer movingImagePyramid = MovingImagePyramidType::New();
472 fixedImagePyramid->SetUseShrinkImageFilter(false);
473 fixedImagePyramid->SetInput(croppedFixedImage);
474 fixedImagePyramid->SetNumberOfLevels(m_ArgsInfo.levels_arg);
475 movingImagePyramid->SetUseShrinkImageFilter(false);
476 movingImagePyramid->SetInput(movingImage);
477 movingImagePyramid->SetNumberOfLevels(m_ArgsInfo.levels_arg);
478 if (m_Verbose) std::cout<<"Creating the image pyramid..."<<std::endl;
479 fixedImagePyramid->Update();
480 movingImagePyramid->Update();
481 typedef clitk::MultiResolutionPyramidRegionFilter<FixedImageType> FixedImageRegionPyramidType;
482 typename FixedImageRegionPyramidType::Pointer fixedImageRegionPyramid=FixedImageRegionPyramidType::New();
483 fixedImageRegionPyramid->SetRegion(metricRegion);
484 fixedImageRegionPyramid->SetSchedule(fixedImagePyramid->GetSchedule());
487 //=======================================================
488 // Rigid or Affine Transform
489 //=======================================================
490 typedef itk::AffineTransform <double,3> RigidTransformType;
491 RigidTransformType::Pointer rigidTransform=NULL;
492 if (m_ArgsInfo.initMatrix_given)
494 if(m_Verbose) std::cout<<"Reading the prior transform matrix "<< m_ArgsInfo.initMatrix_arg<<"..."<<std::endl;
495 rigidTransform=RigidTransformType::New();
496 itk::Matrix<double,4,4> rigidTransformMatrix=clitk::ReadMatrix3D(m_ArgsInfo.initMatrix_arg);
499 itk::Matrix<double,3,3> finalRotation = clitk::GetRotationalPartMatrix3D(rigidTransformMatrix);
500 rigidTransform->SetMatrix(finalRotation);
502 //Set the translation
503 itk::Vector<double,3> finalTranslation = clitk::GetTranslationPartMatrix3D(rigidTransformMatrix);
504 rigidTransform->SetTranslation(finalTranslation);
506 else if (m_ArgsInfo.centre_flag)
508 if(m_Verbose) std::cout<<"No itinial matrix given and \"centre\" flag switched on. Centering all images..."<<std::endl;
510 rigidTransform=RigidTransformType::New();
512 typedef itk::CenteredTransformInitializer<RigidTransformType, FixedImageType, MovingImageType > TransformInitializerType;
513 typename TransformInitializerType::Pointer initializer = TransformInitializerType::New();
514 initializer->SetTransform( rigidTransform );
515 initializer->SetFixedImage( fixedImage );
516 initializer->SetMovingImage( movingImage );
517 initializer->GeometryOn();
518 initializer->InitializeTransform();
522 //=======================================================
523 // B-LUT FFD Transform
524 //=======================================================
525 typedef clitk::MultipleBSplineDeformableTransform<TCoordRep,InputImageType::ImageDimension, SpaceDimension > TransformType;
526 typename TransformType::Pointer transform = TransformType::New();
527 if (labels) transform->SetLabels(labels);
528 if (rigidTransform) transform->SetBulkTransform(rigidTransform);
530 //-------------------------------------------------------------------------
531 // The transform initializer
532 //-------------------------------------------------------------------------
533 typedef clitk::MultipleBSplineDeformableTransformInitializer< TransformType,FixedImageType> InitializerType;
534 typename InitializerType::Pointer initializer = InitializerType::New();
535 initializer->SetVerbose(m_Verbose);
536 initializer->SetImage(fixedImagePyramid->GetOutput(0));
537 initializer->SetTransform(transform);
539 //-------------------------------------------------------------------------
541 //-------------------------------------------------------------------------
542 typename FixedImageType::RegionType::SizeType splineOrders ;
543 splineOrders.Fill(3);
544 if (m_ArgsInfo.order_given)
545 for(unsigned int i=0; i<InputImageType::ImageDimension;i++)
546 splineOrders[i]=m_ArgsInfo.order_arg[i];
547 if (m_Verbose) std::cout<<"Setting the spline orders to "<<splineOrders<<"..."<<std::endl;
548 initializer->SetSplineOrders(splineOrders);
550 //-------------------------------------------------------------------------
552 //-------------------------------------------------------------------------
555 if (m_ArgsInfo.spacing_given)
557 initializer->m_ControlPointSpacingArray.resize(m_ArgsInfo.levels_arg);
558 initializer->SetControlPointSpacing(m_ArgsInfo.spacing_arg);
559 initializer->m_ControlPointSpacingArray[m_ArgsInfo.levels_arg-1]=initializer->m_ControlPointSpacing;
560 if (m_Verbose) std::cout<<"Using a control point spacing of "<<initializer->m_ControlPointSpacingArray[m_ArgsInfo.levels_arg-1]
561 <<" at level "<<m_ArgsInfo.levels_arg<<" of "<<m_ArgsInfo.levels_arg<<"..."<<std::endl;
563 for (int i=1; i<m_ArgsInfo.levels_arg; i++ )
565 initializer->m_ControlPointSpacingArray[m_ArgsInfo.levels_arg-1-i]=initializer->m_ControlPointSpacingArray[m_ArgsInfo.levels_arg-i]*2;
566 if (m_Verbose) std::cout<<"Using a control point spacing of "<<initializer->m_ControlPointSpacingArray[m_ArgsInfo.levels_arg-1-i]
567 <<" at level "<<m_ArgsInfo.levels_arg-i<<" of "<<m_ArgsInfo.levels_arg<<"..."<<std::endl;
573 if (m_ArgsInfo.control_given)
575 initializer->m_NumberOfControlPointsInsideTheImageArray.resize(m_ArgsInfo.levels_arg);
576 initializer->SetNumberOfControlPointsInsideTheImage(m_ArgsInfo.control_arg);
577 initializer->m_NumberOfControlPointsInsideTheImageArray[m_ArgsInfo.levels_arg-1]=initializer->m_NumberOfControlPointsInsideTheImage;
578 if (m_Verbose) std::cout<<"Using "<< initializer->m_NumberOfControlPointsInsideTheImageArray[m_ArgsInfo.levels_arg-1]<<"control points inside the image"
579 <<" at level "<<m_ArgsInfo.levels_arg<<" of "<<m_ArgsInfo.levels_arg<<"..."<<std::endl;
581 for (int i=1; i<m_ArgsInfo.levels_arg; i++ )
583 for(unsigned int j=0;j<InputImageType::ImageDimension;j++)
584 initializer->m_NumberOfControlPointsInsideTheImageArray[m_ArgsInfo.levels_arg-1-i][j]=ceil ((double)initializer->m_NumberOfControlPointsInsideTheImageArray[m_ArgsInfo.levels_arg-i][j]/2.);
585 // initializer->m_NumberOfControlPointsInsideTheImageArray[m_ArgsInfo.levels_arg-1-i]=ceil ((double)initializer->m_NumberOfControlPointsInsideTheImageArray[m_ArgsInfo.levels_arg-i]/2.);
586 if (m_Verbose) std::cout<<"Using "<< initializer->m_NumberOfControlPointsInsideTheImageArray[m_ArgsInfo.levels_arg-1-i]<<"control points inside the image"
587 <<" at level "<<m_ArgsInfo.levels_arg<<" of "<<m_ArgsInfo.levels_arg<<"..."<<std::endl;
592 // Inialize on the first level
593 if (m_ArgsInfo.verbose_flag) std::cout<<"Initializing transform for level 1 of "<<m_ArgsInfo.levels_arg<<"..."<<std::endl;
594 if (m_ArgsInfo.spacing_given) initializer->SetControlPointSpacing( initializer->m_ControlPointSpacingArray[0]);
595 if (m_ArgsInfo.control_given) initializer->SetNumberOfControlPointsInsideTheImage(initializer->m_NumberOfControlPointsInsideTheImageArray[0]);
596 if (m_ArgsInfo.samplingFactor_given) initializer->SetSamplingFactors(m_ArgsInfo.samplingFactor_arg);
599 initializer->InitializeTransform();
601 //-------------------------------------------------------------------------
602 // Initial parameters (passed by reference)
603 //-------------------------------------------------------------------------
604 typedef typename TransformType::ParametersType ParametersType;
605 const unsigned int numberOfParameters = transform->GetNumberOfParameters();
606 ParametersType parameters(numberOfParameters);
607 parameters.Fill( 0.0 );
608 transform->SetParameters( parameters );
609 if (m_ArgsInfo.initCoeff_given) initializer->SetInitialParameters(m_ArgsInfo.initCoeff_arg, parameters);
611 //-------------------------------------------------------------------------
612 // DEBUG: use an itk BSpline instead of multilabel BLUTs
613 //-------------------------------------------------------------------------
614 typedef itk::Transform< TCoordRep, 3, 3 > RegistrationTransformType;
615 RegistrationTransformType::Pointer regTransform(transform);
616 typedef itk::BSplineDeformableTransform<TCoordRep,SpaceDimension, 3> SingleBSplineTransformType;
617 typename SingleBSplineTransformType::Pointer sTransform;
618 if(m_ArgsInfo.itkbspline_flag) {
619 if( transform->GetTransforms().size()>1)
620 itkExceptionMacro(<< "invalid --itkbspline option if there is more than 1 label")
621 sTransform = SingleBSplineTransformType::New();
622 sTransform->SetBulkTransform( transform->GetTransforms()[0]->GetBulkTransform() );
623 sTransform->SetGridSpacing( transform->GetTransforms()[0]->GetGridSpacing() );
624 sTransform->SetGridOrigin( transform->GetTransforms()[0]->GetGridOrigin() );
625 sTransform->SetGridRegion( transform->GetTransforms()[0]->GetGridRegion() );
626 sTransform->SetParameters( transform->GetTransforms()[0]->GetParameters() );
627 regTransform = sTransform;
628 transform = NULL; // free memory
631 //=======================================================
633 //=======================================================
634 typedef clitk::GenericInterpolator<args_info_clitkBLUTDIR, FixedImageType, TCoordRep > GenericInterpolatorType;
635 typename GenericInterpolatorType::Pointer genericInterpolator=GenericInterpolatorType::New();
636 genericInterpolator->SetArgsInfo(m_ArgsInfo);
637 typedef itk::InterpolateImageFunction< FixedImageType, TCoordRep > InterpolatorType;
638 typename InterpolatorType::Pointer interpolator=genericInterpolator->GetInterpolatorPointer();
641 //=======================================================
643 //=======================================================
644 typedef clitk::GenericMetric<args_info_clitkBLUTDIR, FixedImageType,MovingImageType > GenericMetricType;
645 typename GenericMetricType::Pointer genericMetric=GenericMetricType::New();
646 genericMetric->SetArgsInfo(m_ArgsInfo);
647 genericMetric->SetFixedImage(fixedImagePyramid->GetOutput(0));
648 if (fixedMask) genericMetric->SetFixedImageMask(fixedMask);
649 genericMetric->SetFixedImageRegion(fixedImageRegionPyramid->GetOutput(0));
650 typedef itk::ImageToImageMetric< FixedImageType, MovingImageType > MetricType;
651 typename MetricType::Pointer metric=genericMetric->GetMetricPointer();
652 if (movingMask) metric->SetMovingImageMask(movingMask);
654 metric->SetNumberOfThreads( threads );
655 if (m_Verbose) std::cout<< "Using " << threads << " threads." << std::endl;
658 //=======================================================
660 //=======================================================
661 typedef clitk::GenericOptimizer<args_info_clitkBLUTDIR> GenericOptimizerType;
662 GenericOptimizerType::Pointer genericOptimizer = GenericOptimizerType::New();
663 genericOptimizer->SetArgsInfo(m_ArgsInfo);
664 genericOptimizer->SetMaximize(genericMetric->GetMaximize());
665 genericOptimizer->SetNumberOfParameters(regTransform->GetNumberOfParameters());
666 typedef itk::SingleValuedNonLinearOptimizer OptimizerType;
667 OptimizerType::Pointer optimizer = genericOptimizer->GetOptimizerPointer();
670 //=======================================================
672 //=======================================================
673 typedef itk::MultiResolutionImageRegistrationMethod< FixedImageType, MovingImageType > RegistrationType;
674 typename RegistrationType::Pointer registration = RegistrationType::New();
675 registration->SetMetric( metric );
676 registration->SetOptimizer( optimizer );
677 registration->SetInterpolator( interpolator );
678 registration->SetTransform (regTransform );
680 registration->SetNumberOfThreads(threads);
681 if (m_Verbose) std::cout<< "Using " << threads << " threads." << std::endl;
683 registration->SetFixedImage( croppedFixedImage );
684 registration->SetMovingImage( movingImage );
685 registration->SetFixedImageRegion( metricRegion );
686 registration->SetFixedImagePyramid( fixedImagePyramid );
687 registration->SetMovingImagePyramid( movingImagePyramid );
688 registration->SetInitialTransformParameters( regTransform->GetParameters() );
689 registration->SetNumberOfLevels( m_ArgsInfo.levels_arg );
690 if (m_Verbose) std::cout<<"Setting the number of resolution levels to "<<m_ArgsInfo.levels_arg<<"..."<<std::endl;
693 //================================================================================================
695 //================================================================================================
698 // Output iteration info
699 CommandIterationUpdate::Pointer observer = CommandIterationUpdate::New();
700 observer->SetOptimizer(genericOptimizer);
701 optimizer->AddObserver( itk::IterationEvent(), observer );
704 typedef RegistrationInterfaceCommand<RegistrationType,args_info_clitkBLUTDIR> CommandType;
705 typename CommandType::Pointer command = CommandType::New();
706 command->SetInitializer(initializer);
707 command->SetArgsInfo(m_ArgsInfo);
708 command->SetCommandIterationUpdate(observer);
709 command->SetMaximize(genericMetric->GetMaximize());
710 command->SetMetricRegion(metricRegion);
711 registration->AddObserver( itk::IterationEvent(), command );
713 if (m_ArgsInfo.coeff_given)
715 if(m_ArgsInfo.itkbspline_flag) {
716 itkExceptionMacro("--coeff and --itkbpline are incompatible");
719 std::cout << std::endl << "Output coefficient images every " << m_ArgsInfo.coeffEveryN_arg << " iterations." << std::endl;
720 typedef CommandIterationUpdateDVF<FixedImageType, OptimizerType, TransformType> DVFCommandType;
721 typename DVFCommandType::Pointer observerdvf = DVFCommandType::New();
722 observerdvf->SetFixedImage(fixedImage);
723 observerdvf->SetTransform(transform);
724 observerdvf->SetArgsInfo(m_ArgsInfo);
725 optimizer->AddObserver( itk::IterationEvent(), observerdvf );
730 //=======================================================
732 //=======================================================
733 if (m_Verbose) std::cout << std::endl << "Starting Registration" << std::endl;
737 registration->Update();
739 catch( itk::ExceptionObject & err )
741 std::cerr << "ExceptionObject caught while registering!" << std::endl;
742 std::cerr << err << std::endl;
747 //=======================================================
749 //=======================================================
750 OptimizerType::ParametersType finalParameters = registration->GetLastTransformParameters();
751 regTransform->SetParameters( finalParameters );
754 std::cout<<"Stop condition description: "
755 <<registration->GetOptimizer()->GetStopConditionDescription()<<std::endl;
759 //=======================================================
760 // Get the BSpline coefficient images and write them
761 //=======================================================
762 if (m_ArgsInfo.coeff_given)
764 typedef typename TransformType::CoefficientImageType CoefficientImageType;
765 std::vector<typename CoefficientImageType::Pointer> coefficientImages = transform->GetCoefficientImages();
766 typedef itk::ImageFileWriter<CoefficientImageType> CoeffWriterType;
767 typename CoeffWriterType::Pointer coeffWriter = CoeffWriterType::New();
768 unsigned nLabels = transform->GetnLabels();
770 std::string fname(m_ArgsInfo.coeff_arg);
771 int dotpos = fname.length() - 1;
772 while (dotpos >= 0 && fname[dotpos] != '.')
775 for (unsigned i = 0; i < nLabels; ++i)
777 std::ostringstream osfname;
778 osfname << fname.substr(0, dotpos) << '_' << i << fname.substr(dotpos);
779 coeffWriter->SetInput(coefficientImages[i]);
780 coeffWriter->SetFileName(osfname.str());
781 coeffWriter->Update();
787 //=======================================================
788 // Compute the DVF (only deformable transform)
789 //=======================================================
790 typedef itk::Vector< float, SpaceDimension > DisplacementType;
791 typedef itk::Image< DisplacementType, InputImageType::ImageDimension > DisplacementFieldType;
792 #if ITK_VERSION_MAJOR >= 4
793 # if ITK_VERSION_MINOR < 6
794 typedef itk::TransformToDisplacementFieldSource<DisplacementFieldType, double> ConvertorType;
796 typedef itk::TransformToDisplacementFieldFilter<DisplacementFieldType, double> ConvertorType;
799 typename ConvertorType::Pointer filter= ConvertorType::New();
800 filter->SetNumberOfThreads(1);
801 if(m_ArgsInfo.itkbspline_flag)
802 sTransform->SetBulkTransform(NULL);
804 transform->SetBulkTransform(NULL);
805 filter->SetTransform(regTransform);
806 #if ITK_VERSION_MAJOR > 4 || (ITK_VERSION_MAJOR == 4 && ITK_VERSION_MINOR >= 6)
807 filter->SetReferenceImage(fixedImage);
809 filter->SetOutputParametersFromImage(fixedImage);
812 typename DisplacementFieldType::Pointer field = filter->GetOutput();
815 //=======================================================
817 //=======================================================
818 typedef itk::ImageFileWriter< DisplacementFieldType > FieldWriterType;
819 typename FieldWriterType::Pointer fieldWriter = FieldWriterType::New();
820 fieldWriter->SetFileName( m_ArgsInfo.vf_arg );
821 fieldWriter->SetInput( field );
824 fieldWriter->Update();
826 catch( itk::ExceptionObject & excp )
828 std::cerr << "Exception thrown writing the DVF" << std::endl;
829 std::cerr << excp << std::endl;
834 //=======================================================
835 // Resample the moving image
836 //=======================================================
837 typedef itk::ResampleImageFilter< MovingImageType, FixedImageType > ResampleFilterType;
838 typename ResampleFilterType::Pointer resampler = ResampleFilterType::New();
839 if (rigidTransform) {
840 if(m_ArgsInfo.itkbspline_flag)
841 sTransform->SetBulkTransform(rigidTransform);
843 transform->SetBulkTransform(rigidTransform);
845 resampler->SetTransform( regTransform );
846 resampler->SetInput( movingImage);
847 resampler->SetOutputParametersFromImage(fixedImage);
849 typename FixedImageType::Pointer result=resampler->GetOutput();
851 // typedef itk::WarpImageFilter< MovingImageType, FixedImageType, DeformationFieldType > WarpFilterType;
852 // typename WarpFilterType::Pointer warp = WarpFilterType::New();
854 // warp->SetDeformationField( field );
855 // warp->SetInput( movingImageReader->GetOutput() );
856 // warp->SetOutputOrigin( fixedImage->GetOrigin() );
857 // warp->SetOutputSpacing( fixedImage->GetSpacing() );
858 // warp->SetOutputDirection( fixedImage->GetDirection() );
859 // warp->SetEdgePaddingValue( 0.0 );
863 //=======================================================
864 // Write the warped image
865 //=======================================================
866 typedef itk::ImageFileWriter< FixedImageType > WriterType;
867 typename WriterType::Pointer writer = WriterType::New();
868 writer->SetFileName( m_ArgsInfo.output_arg );
869 writer->SetInput( result );
875 catch( itk::ExceptionObject & err )
877 std::cerr << "ExceptionObject caught !" << std::endl;
878 std::cerr << err << std::endl;
883 //=======================================================
884 // Calculate the difference after the deformable transform
885 //=======================================================
886 typedef clitk::DifferenceImageFilter< FixedImageType, FixedImageType> DifferenceFilterType;
887 if (m_ArgsInfo.after_given)
889 typename DifferenceFilterType::Pointer difference = DifferenceFilterType::New();
890 difference->SetValidInput( fixedImage );
891 difference->SetTestInput( result );
895 difference->Update();
897 catch( itk::ExceptionObject & err )
899 std::cerr << "ExceptionObject caught calculating the difference !" << std::endl;
900 std::cerr << err << std::endl;
904 typename WriterType::Pointer differenceWriter=WriterType::New();
905 differenceWriter->SetInput(difference->GetOutput());
906 differenceWriter->SetFileName(m_ArgsInfo.after_arg);
907 differenceWriter->Update();
912 //=======================================================
913 // Calculate the difference before the deformable transform
914 //=======================================================
915 if( m_ArgsInfo.before_given )
918 typename FixedImageType::Pointer moving=FixedImageType::New();
919 if (m_ArgsInfo.initMatrix_given)
921 typedef itk::ResampleImageFilter<MovingImageType, FixedImageType> ResamplerType;
922 typename ResamplerType::Pointer resampler=ResamplerType::New();
923 resampler->SetInput(movingImage);
924 resampler->SetOutputOrigin(fixedImage->GetOrigin());
925 resampler->SetSize(fixedImage->GetLargestPossibleRegion().GetSize());
926 resampler->SetOutputSpacing(fixedImage->GetSpacing());
927 resampler->SetDefaultPixelValue( 0. );
928 if (rigidTransform ) resampler->SetTransform(rigidTransform);
930 moving=resampler->GetOutput();
935 typename DifferenceFilterType::Pointer difference = DifferenceFilterType::New();
936 difference->SetValidInput( fixedImage );
937 difference->SetTestInput( moving );
941 difference->Update();
943 catch( itk::ExceptionObject & err )
945 std::cerr << "ExceptionObject caught calculating the difference !" << std::endl;
946 std::cerr << err << std::endl;
950 typename WriterType::Pointer differenceWriter=WriterType::New();
951 writer->SetFileName( m_ArgsInfo.before_arg );
952 writer->SetInput( difference->GetOutput() );
961 #endif // #define clitkBLUTDIRGenericFilter_txx